LongOmicsTraj - Longitudinal Omics Trajectory Clustering and Analysis Engine

Provides methods for estimating, classifying and comparing longitudinal molecular trajectories across repeated study visits using empirical, mixed-effects, generalized additive model and polynomial regression estimators. Consecutive molecular changes are converted into interpretable Omics Trajectory Signatures (OTS) describing stable, sustained, transient and rebound temporal behaviours, enabling topology- aware clustering and consensus trajectory inference. LongOmicsTraj further provides a flexible query framework for directly retrieving molecular features satisfying simple or complex trajectory definitions, including multi-transition patterns, logical combinations of trajectory states, group-specific behaviours, and comparisons of trajectory topologies across treatment arms, experimental conditions or other longitudinal study arms.